FCTwente Speelschema 2015/2016
| Zo 9 aug | 14:30 | FC Groningen - FC Twente | ||
| Za 15 aug | 19:45 | FC Twente - ADO Den Haag | ||
| Zo 23 aug | 12:30 | PEC Zwolle - FC Twente | ||
| Za 29 aug | 20:45 | Heracles - FC Twente | ||
| Za 12 sep | 19:45 | FC Twente - Ajax | ||
| Za 19 sep. | 18:30 | Cambuur - FC Twente | ||
| Zo 27 sep. | 16:45 | FC Twente - Roda JC | ||
| Zo 4 okt. | 16:45 | AZ - FC Twente | ||
| Zo 18 okt | 12:30 | FC Twente - NEC | ||
| Za 24 okt | 19:45 | FC Twente - PSV | ||
| Zo 1 nov | 14:30 | FC Utrecht - FC Twente | ||
| Za 7 nov | 18:30 | FC Twente - sc Heerenveen | ||
| Zo 22 nov | 14:30 | Feyenoord - FC Twente | ||
| Za 28 nov | 20:45 | FC Twente - Willem II | ||
| Za 5 dec | 18:30 | Excelsior - FC Twente | ||
| Za 12 dec | 20:45 | FC Twente - De Graafschap | ||
| Vr 18 dec | 20:00 | Vitesse - FC Twente | ||
Winterstop | ||||
| Vr 15 jan | 20:00 | FC Twente - Heracles | ||
| Zo 24 jan | 14:30 | PSV - FC Twente | ||
| Wo 27 jan | 18:30 | NEC - FC Twente | ||
| Zo 31 jan | 16:45 | FC Twente - FC Utrecht | ||
| Za 6 feb | 19:45 | sc Heerenveen - FC Twente | ||
| Za 13 feb | 19:45 | Roda JC - FC Twente | ||
| Za 20 feb | 20:45 | FC Twente - Cambuur | ||
| Za 27 feb | 18:30 | FC Twente - FC Groningen | ||
| Vr 4 mrt | 20:00 | ADO Den Haag - FC Twente | ||
| Za 12 mrt | 18:30 | FC Twente - PEC Zwolle | ||
| Zo 20 mrt | 12:30 | FC Twente - AZ | ||
| Za 2 apr | 20:45 | Willem II - FC Twente | ||
| Zo 10 apr | 16:45 | FC Twente - Feyenoord | ||
| Vr 15 apr | 20:00 | De Graafschap - FC Twente | ||
| Wo 20 apr | 20:45 | Excelsior - FC Twente | ||
| Zo 1 mei | 14:30 | Ajax - FC Twente | ||
| Zo 8 mei | 14:30 | FC Twente - Vitesse |